Joint Health

Turmeric and saffron exert complementary actions in stabilising neural activity. For instance, turmeric has been shown to activate the enzyme glutamate decarboxylase (GAD), which converts glutamate to GABA, while saffron reduces glutamate activity in the brain via N-methyl-Daspartate (NMDA) receptor antagonism.

Both curcumin and saffron maximise natural serotonin, noradrenaline and dopamine levels in the brain, most likely via inhibition of monoamine oxidase (MAO) activity. Curcumin has also been shown to increase neurogenesis, possibly via modulation of hypothalamic-pituitary-adrenal (HPA) axis, up-regulation of 5-HT1A receptors, and/or via increasing brain derived neurotropic factor (BDNF) production in the brain.